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Type: Artigo de periódico
Title: Atypical Glandular Cells: Criteria To Discriminate Benign From Neoplastic Lesions And Squamous From Glandular Neoplasia.
Author: Torres, J C C
Derchain, S F M
Gontijo, R C
do Amaral Westin, M C
Zeferino, L C
Angelo-Andrade, L A L
Rabelo-Santos, S H
Abstract: To evaluate the presence of some criteria in cervical smears with atypical glandular cells and their correlation with histological patterns to identify pre-neoplastic and neoplastic lesions. Seventy-three women referred with an atypical glandular cell smear, who had undergone conization or hysterectomy, were included in this study. Referral Pap smears were reviewed using the set of 27 cyto-morphological criteria that was correlated with the histological diagnosis. Histological results showed intraepithelial or invasive neoplasia in 35 (48%) cases and benign lesions in 38 (52%) cases. After logistic regression and decision tree analysis an increased nuclear/cytoplasmic ratio and the presence of dyskeratotic cells were strongly associated with intraepithelial or invasive neoplasia and the differential cyto-morphological criteria for glandular lesions were decreased cytoplasm, irregular nuclear membranes and the presence of nucleoli. The analysis of individual cyto-morphological criteria can better predict intraepithelial or invasive neoplasia and differentiate glandular from squamous lesions.
Subject: Adult
Analysis Of Variance
Carcinoma, Squamous Cell
Cervical Intraepithelial Neoplasia
Cervix Uteri
Cross-sectional Studies
Diagnosis, Differential
Logistic Models
Middle Aged
Papanicolaou Test
Uterine Cervical Neoplasms
Vaginal Smears
Rights: fechado
Identifier DOI: 10.1111/j.1365-2303.2005.00300.x
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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