Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196489
Type: Artigo de periódico
Title: Abnormal Production Of Transforming Growth Factor Beta And Interferon Gamma By Peripheral Blood Cells Of Patients With Multidrug-resistant Pulmonary Tuberculosis In Brazil.
Author: Castro, Analia Z
Diaz-Bardalez, Blanca M
Oliveira, Elaine C
Garcia, Reinaldo C
Afiune, Jorge Barros
Paschoal, Ilma A
Santos, Leonilda M B
Abstract: The aim of the present study was to determine the immune response profile that differentiates patients with newly diagnosed (non-treated) pulmonary tuberculosis from multidrug-resistant (MDR) ones, as well as from healthy, tuberculin positive individuals. Lymphocytes proliferative response to non-specific mitogen (PHA) and PPD were evaluated by 3H thymidine incorporation and cytokines were quantified using an ELISA assay. Patients with active disease showed a diminished proliferative response to PHA and PPD, while multidrug-resistant patients showed a diminished proliferative response to PHA, but a normal response to PPD. The cytokine production of newly diagnosed patients was characterized by a diminished production of IFNgamma and normal production of transforming growth factor (TGFbeta), while MDR patients revealed a normal production of IFNgamma accompanied by an increase in TGFbeta. The production of significant amounts of TGFbeta in MDR patients leads to a poor immune response and may contribute to the resistance of tuberculosis patients to drugs.
Subject: Adult
Brazil
Case-control Studies
Drug Resistance, Multiple
Enzyme-linked Immunosorbent Assay
Female
Humans
Immunity, Cellular
Interferon-gamma
Leukocytes, Mononuclear
Lymphocyte Activation
Lymphocytes
Male
Middle Aged
Mitogens
Mycobacterium Tuberculosis
Transforming Growth Factor Beta
Tuberculin
Tuberculosis, Pulmonary
Rights: fechado
Identifier DOI: 10.1016/j.jinf.2004.08.035
Address: http://www.ncbi.nlm.nih.gov/pubmed/16291285
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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