Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196456
Type: Artigo de periódico
Title: Low-renin (volume Dependent) Mild-hypertensive Patients Have Impaired Flow-mediated And Glyceryl-trinitrate Stimulated Vascular Reactivity.
Author: Yugar-Toledo, Juan Carlos
Bonalume Tácito, Lúcia Helena
Ferreira-Melo, Sílvia Elaine
Sousa, Walnéia
Consolin-Colombo, Fernanda
Irigoyen, Maria Cláudia
Franchini, Kléber
Coelho, Otávio Rizzi
Moreno, Heitor
Abstract: Low-renin (volume-dependent) hypertension represents 25-30% of all cases of primary hypertension. Endothelial dysfunction and vascular remodeling are associated with hypertension but their relevance to volume-dependent hypertension (VDH) is not yet known. To evaluate this, flow-mediated dilation (FMD) of the brachial artery and the carotid intima-media thickness in the distal common carotid artery were measured and compared between renin-dependent mild-hypertensive patients (RDH) and controls. The study group comprised 40 mild-hypertensive patients and 25 controls. Plasma renin activity (PRA), plasma aldosterone concentration, angiotensin II and nitrite/nitrate plasma levels were measured. According to PRA, subjects were classified as VDH (<0.6 ng . ml (-1) . h(-1)), or RDH (>0.6 ng . ml(-1) . h (-1)). Vascular function was evaluated by FMD before and after reactive hyperemia (RH) and glyceryl-trinitrate (GTN) administration. FMD in response to RH and GTN in the VDH group when compared with RDH group was 10.2+/-2.8% vs 13.3+/-3.6% (p=0.01); and 16.0+/-3.5% vs 19.9+/-4.5% (p=0.01), respectively. This study showed impaired FMD and reduced GTN response in mildly hypertensive patients with low-renin plasma levels.
Subject: Adult
Brachial Artery
Carotid Artery, Common
Case-control Studies
Female
Humans
Hypertension
Male
Middle Aged
Nitroglycerin
Renin
Tunica Intima
Vasodilation
Vasodilator Agents
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/16247215
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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