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Type: Artigo de periódico
Title: Surveillance Of Cytomegalovirus Infection In Haematopoietic Stem Cell Transplantation Patients.
Author: Bonon, Sandra H A
Menoni, Silvia M F
Rossi, Cláudio L
De Souza, Cármino A
Vigorito, Afonso C
Costa, Daniel B
Costa, Sandra C B
Abstract: The aim of this study was to describe our experience in the control of active CMV infection following HSCT using two strategies of CMV infection treatment: ganciclovir universal prophylaxis at low doses and pre-emptive therapy with ganciclovir. The surveillance was based on the monitoring of antigenaemia (AGM) and on a nested polymerase chain reaction (N-PCR) for the detection of CMV in both strategies. Forty-five recipients with malignant diseases and with a risk for CMV disease received universal prophylaxis (Group A). The non-treated group consisted of 24 patients, most of them with non-malignant diseases who did not receive universal prophylaxis (Group B). In Group A, the incidence of positive AGM was 51%, with a positive PCR of 68.9%. In Group B, the AGM positivity was 66.7% and that of N-PCR was 66.7%. CMV disease occurred in 6/55 patients (10.9%), with 2/36 (5.5%) from Group A and 4/19 (21%) from Group B. Two of these six patients (33.3%) died of CMV disease. Our result suggests that AGM and N-PCR can be used as markers for assessing the monitoring and the introduction pre-emptive therapy. This approach could prove to be more cost-effective than ganciclovir universal prophylaxis for treating CMV infection.
Subject: Adolescent
Antiviral Agents
Child, Preschool
Cytomegalovirus Infections
Hematopoietic Stem Cell Transplantation
Middle Aged
Polymerase Chain Reaction
Population Surveillance
Viral Matrix Proteins
Citation: The Journal Of Infection. v. 50, n. 2, p. 130-7, 2005-Feb.
Rights: fechado
Identifier DOI: 10.1016/j.jinf.2003.11.010
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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