Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196443
Type: Artigo de periódico
Title: Smoking Affects The Self-healing Capacity Of Periodontal Tissues. A Histological Study In The Rat.
Author: Benatti, Bruno Braga
César-Neto, João Batista
Gonçalves, Patrícia Furtado
Sallum, Enílson Antônio
Nociti, Francisco Humberto
Abstract: This study aimed to evaluate in rats the impact of cigarette smoke inhalation (CSI) and nicotine administration (NA) on a periodontal healing model in the absence of a plaque biofilm. Wistar rats (n = 42) were assigned to three groups: Group 1, control (n = 14); Group 2, NA (3 mg kg(-1)) (n = 14); and Group 3, CSI (n = 14). Thirty days after CSI and NA exposure, fenestration defects were created buccally to the distal root of the first mandibular molar. The animals were killed 21 d later and their mandibles were processed for histological examination. The percentage of bone fill and the density of newly formed bone were assessed histometrically. Intergroup analysis demonstrated that compared to the control and NA groups, CSI was associated with a reduced rate of bone repair. No new cementum had been formed along the root surface in any of the three groups. It is concluded that cigarette smoke reduces the self-healing capacity of periodontal tissues.
Subject: Alveolar Bone Loss
Alveolar Process
Animals
Carbon Monoxide
Disease Models, Animal
Male
Nicotine
Nicotinic Agonists
Osteoblasts
Periodontal Attachment Loss
Periodontal Diseases
Periodontium
Random Allocation
Rats
Rats, Wistar
Smoke
Smoking
Wound Healing
Rights: fechado
Identifier DOI: 10.1111/j.1600-0722.2005.00240.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/16202027
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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