Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Misoprostol Versus Expectant Management In Premature Rupture Of Membranes At Term.
Author: da Graça Krupa, Fabiana
Cecatti, José Guilherme
de Castro Surita, Fernanda Garanhani
Milanez, Helaine Maria Besteti Pires
Parpinelli, Mary Angela
Abstract: To compare the effectiveness of immediate induction of labour with vaginal misoprostol versus expectant management for 24 hours followed by oxytocin induction in women with premature rupture of membranes at term (term PROM). An open, randomised, controlled trial. Public university hospital in Campinas City, Brazil. One hundred and fifty pregnancies, half of them allocated to each group. Statistical analysis used Student's t test, the chi2 test, Fisher's exact test, survival analysis and risk ratio estimates with 95% CI. Latency period, recruitment to delivery period, period of hospitalisation, mode of delivery, contractility pattern, fetal wellbeing, labour and delivery complications, neonatal and maternal morbidity. Both groups had similar general characteristics, but the misoprostol group had a significantly shorter latency period (9.4 vs 15.8 hours), a shorter time interval from recruitment to delivery (18.9 vs 27.5 hours), a shorter period of maternal hospitalisation and a slightly higher proportion of alterations of contractility when compared with the expectant group. Caesarean section rates were 20% in the misoprostol group and 30.7% in the other. There were no differences between them regarding fetal wellbeing, complications during labour and delivery and neonatal or postpartum maternal morbidity. Within 24 hours, 44% of women had delivered in the expectant group against 73.3% in the misoprostol group. Immediate labour induction with misoprostol in cases of term PROM shortens the latency period, the total time between recruitment to delivery and the time of maternal hospitalisation, increasing the occurrence of alterations of contractility without any maternal and perinatal outcomes disadvantages.
Subject: Abortifacient Agents, Nonsteroidal
Apgar Score
Cesarean Section
Fetal Membranes, Premature Rupture
Labor, Induced
Length Of Stay
Myocardial Contraction
Pregnancy Outcome
Risk Factors
Citation: Bjog : An International Journal Of Obstetrics And Gynaecology. v. 112, n. 9, p. 1284-90, 2005-Sep.
Rights: fechado
Identifier DOI: 10.1111/j.1471-0528.2005.00700.x
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_16101609.pdf201.45 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.