Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196367
Type: Artigo de periódico
Title: Late Effects Of Chronic Graft-vs.-host Disease In Minor Salivary Glands.
Author: Alborghetti, M R
Corrêa, M E P
Adam, R L
Metze, K
Coracin, F L
de Souza, C A
Cintra, M L
Abstract: The established pathologic criteria for minor salivary gland (MSG) involvement in chronic graft-vs.-host disease (cGVHD) could play a role in monitoring response to therapy. We evaluated MSG sequential biopsies during cGVHD therapy in 14 allogeneic bone marrow transplantation (BMT) patients. Nine patients that did not develop GVHD after BMT entered the control group. Biopsies were examined using hematoxylin-eosin, Periodic acid-Schiff (PAS) and leukocyte common antigen staining. A significant loss of PAS+ acinar volume was observed at the diagnosis of cGVHD as much as at the end of treatment when compared with the control group. In the second evaluation, the inflammatory infiltrate was still greater than control group. The results suggest that persistent xerostomia after cGVHD treatment is because of maintenance of lymphocytic infiltrate and consequent absence of MSG secretory unit recovery. This data may be useful to provide improved insight into the histopathology of this organ involvement.
Subject: Adolescent
Adult
Anti-inflammatory Agents
Biopsy
Bone Marrow Transplantation
Case-control Studies
Chronic Disease
Cyclosporine
Female
Graft Vs Host Disease
Humans
Immunosuppressive Agents
Leukemia, Myeloid
Male
Middle Aged
Periodic Acid-schiff Reaction
Prednisone
Salivary Glands, Minor
Xerostomia
Rights: fechado
Identifier DOI: 10.1111/j.1600-0714.2005.00347.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/16091116
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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