Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196341
Type: Artigo de periódico
Title: A Novel Method For Subarachnoid Drug Delivery In The Medullary Region Of Rats.
Author: Fischer, Luana
Parada, Carlos Amílcar
Tambeli, Cláudia Herrera
Abstract: This study describes a novel method for direct subarachnoid drug delivery to the medullary dorsal horn region of rats, without introducing a catheter. The reliability of the method was demonstrated by a pharmacological validation; that is, morphine administration to the medullary region blocked the nociceptive response to formalin injected in the temporomandibular joint (TMJ) region, an effect that was prevented by co-administration of naloxone. The method proposed offers many advantages over the existing methods for medullary drug delivery with catheter implantation. It is easy to be employed, it does not induce any sign of motor impairment, and it does not require the neck surgery performed to implant a catheter in the medullary dorsal horn region. Therefore, it is a useful method for subarachnoid drug delivery in behavioral trigeminal pain studies, particularly when nociceptive behavioral measures that require normal neck muscle activity to occur, such as head withdraw or head flinch, are evaluated.
Subject: Analgesics, Opioid
Animals
Arthralgia
Drug Delivery Systems
Head Movements
Male
Medulla Oblongata
Microinjections
Morphine
Naloxone
Narcotic Antagonists
Neck Muscles
Neurosurgical Procedures
Nociceptors
Pain Measurement
Rats
Rats, Wistar
Subarachnoid Space
Syringes
Temporomandibular Joint Disorders
Trigeminal Caudal Nucleus
Rights: fechado
Identifier DOI: 10.1016/j.jneumeth.2005.04.021
Address: http://www.ncbi.nlm.nih.gov/pubmed/16024089
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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