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Type: Artigo de periódico
Title: Ahsp And Beta-thalassemia: A Possible Genetic Modifier.
Author: dos Santos, Camila Oresco
Costa, Fernando Ferreira
Abstract: The identification of defectives genes underlying inherited diseases has made it clear that patients with the same genotype can have variable clinical expression. Suggestions proposing that the protein AHSP, a alpha-globin specific chaperone could influence disease severity in patients with beta-thalassemia, an inherited disorder characterized by a quantitative deficiency of beta-globin genes. This article presents a review of the AHSP gene structure, function and expression. A discussion of the AHSP gene acknowledgements is presented with an overview of the possible genetic modifier function of AHSP on beta-thalassemia pathophysiology.
Subject: Blood Proteins
Disease Progression
Gene Expression Regulation
Molecular Chaperones
Rights: fechado
Identifier DOI: 10.1080/10245330500067280
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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