Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196324
Type: Artigo de periódico
Title: Polymorphisms Of Interleukin-1 Gene Complex, Il6 And Tumour Necrosis Factor Genes In Chronic Idiopathic Neutropenia Of Adults.
Author: Addas-Carvalho, Marcelo
de Paula, Erich V
Lima, Carmen S P
Saad, Sara T O
Abstract: Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the unexplained decrease in the number of circulating neutrophils. Serum inflammatory cytokines and chemokines are increased in CINA. In addition, cytokines gene polymorphisms are associated with increased levels of respective products and related with inflammatory diseases. The aim of the present study was to investigate the association of polymorphisms of IL1B-511C/T and +3953C/T, IL1RN intron 2, IL6-174G/C and TNF-308G/A genes with CINA. We analysed 29 CINA and controls by polymerase chain reaction and restriction fragment length polymorphism. Statistical analyses were performed using chi2 test, and the Hardy-Weinberg equilibrium (HWE) was investigated. All alleles analysed were in HWE in both populations. Similar frequencies of IL1B-511C/T, IL1B+3953C/T, IL1RN, IL6-174G/C and TNF-308G/A genotypes were observed in CINA and controls. These results suggest that cytokine polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of CINA and were not responsible for the increased cytokine in CINA patients.
Subject: Adult
Aged
Aged, 80 And Over
Female
Humans
Interleukin-1
Interleukin-6
Male
Middle Aged
Multigene Family
Neutropenia
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Tumor Necrosis Factor-alpha
Rights: fechado
Identifier DOI: 10.1007/s00277-005-1066-9
Address: http://www.ncbi.nlm.nih.gov/pubmed/15986200
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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