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Type: Artigo de periódico
Title: One-week Dual Therapy With Ranitidine Bismuth Citrate And Clarithromycin For The Treatment Of Helicobacter Pylori Infection In Brazilian Patients With Peptic Ulcer.
Author: Mesquita, Maria Aparecida
Lorena, Sonia Letícia Silva
Almeida, Jazon Romilson Souza
Montes, Ciro Garcia
Guerrazzi, Fábio
Campos, Luciana T
Zeitune, José Murilo Rubiota
Abstract: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer. One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment. By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P>0.05). By per protocol analysis, the eradication rates were 80% and 83%, respectively, in patients treated for 1 or 2 wk (P>0.05). Nine patients (8.2%) reported minor side effects. One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for treatment of H pylori infection, and appears to be comparable to the 2-wk regimen in terms of efficacy.
Subject: Adult
Anti-bacterial Agents
Anti-ulcer Agents
Drug Therapy, Combination
Helicobacter Infections
Helicobacter Pylori
Middle Aged
Peptic Ulcer
Treatment Outcome
Citation: World Journal Of Gastroenterology : Wjg. v. 11, n. 23, p. 3566-9, 2005-Jun.
Rights: aberto
Identifier DOI: 
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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