Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196303
Type: Artigo de periódico
Title: Interphase-fish Study In Three Patients With Tetraploid/diploid Mosaicism.
Author: Cavalcanti, Denise P
Zanchetta, Luciene M
Abstract: We report tetraploid/diploid mosaicism in a boy and two girls detected by cultured skin fibroblasts. In all these children, interphase-FISH using DXZ1 probe confirmed the original karyotype. Tetraploid mosaicism was also confirmed by alpha-satellite probes from chromosomes 2, 6, 7, 9, 10, 17, 18 and Y in fibroblasts from the boy. The common features in these children are failure to thrive, slight mental deficiency and some degree of body asymmetry. The advantage of using interphase-FISH is the possibility of analysing a great number of cells in short time, thus giving a more precise percentage with regard to abnormal cells.
Subject: Abnormalities, Multiple
Cells, Cultured
Child
Child, Preschool
Diploidy
Female
Fibroblasts
Humans
In Situ Hybridization, Fluorescence
Infant
Interphase
Lymphocytes
Male
Mosaicism
Polyploidy
Skin
Rights: fechado
Identifier DOI: 10.1016/j.ejmg.2005.01.009
Address: http://www.ncbi.nlm.nih.gov/pubmed/15953405
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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