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Type: Artigo de periódico
Title: Chronic Gvhd In Minor Salivary Glands And Oral Mucosa: Histopathological And Immunohistochemical Evaluation Of 25 Patients.
Author: Soares, A B
Faria, P R
Magna, L A
Correa, M E P
de Sousa, C A
Almeida, O P
Cintra, M L
Abstract: Graft-vs.-host disease (GVHD) is the major cause of morbidity and mortality in patients undergoing allogeneic Bone Marrow Transplantation (BMT). The aim of our study was to identify the most relevant histological features for diagnosis of chronic Graft-vs.-Host Disease (cGVHD) in oral mucosa and minor salivary glands of 25 patients, as well as to evaluate the immunophenotype of the inflammatory cells. Sixteen patients that were submitted to allogeneic BMT but did not present cGVHD were selected as a control group. The sections were studied on H & E and CD68, CD45, CD4, CD8, CD20 staining. The most frequent histologic findings in oral mucosa at the day of diagnosis of cGVHD were: hydropic degeneration of the basal layer of the epithelium, apoptotic bodies, lymphocytic infiltration, and focal or total cleavage between the epithelial and connective tissue. In the labial salivary glands (LSG), lymphocytic infiltration, acinar loss and fibrosis were the main alterations. Cytotoxic CD8-T cells and macrophages were predominant both in the epithelium and connective tissue, as well as in minor salivary glands. Histological features were useful in the diagnosis of oral cGVHD. It is suggested that CD8-T cells and macrophages play important role in the pathogenesis of the disease.
Subject: Adolescent
Antigens, Cd
Antigens, Cd20
Antigens, Cd4
Antigens, Cd45
Antigens, Cd8
Antigens, Differentiation, Myelomonocytic
Cd8-positive T-lymphocytes
Chronic Disease
Connective Tissue
Graft Vs Host Disease
Middle Aged
Mouth Diseases
Mouth Mucosa
Retrospective Studies
Salivary Gland Diseases
Salivary Glands, Minor
Citation: Journal Of Oral Pathology & Medicine : Official Publication Of The International Association Of Oral Pathologists And The American Academy Of Oral Pathology. v. 34, n. 6, p. 368-73, 2005-Jul.
Rights: fechado
Identifier DOI: 10.1111/j.1600-0714.2005.00322.x
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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