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dc.typeArtigo de periódicopt_BR
dc.titleExpression And Localization Of Nk(1)r, Substance P And Cgrp Are Altered In Dorsal Root Ganglia Neurons Of Spontaneously Hypertensive Rats (shr).pt_BR
dc.contributor.authorAline Boer, Patríciapt_BR
dc.contributor.authorUeno, Mirianpt_BR
dc.contributor.authorSant'ana, Jenifer S Mpt_BR
dc.contributor.authorSaad, Mário J Apt_BR
dc.contributor.authorGontijo, José Antonio Rochapt_BR
unicamp.authorPatrícia Aline Boer, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Laboratório Balanço Hidro-Salino, Núcleo de Medicina e Cirurgia Experimental, Universidade Estadual de Campinas (UNICAMP), 13083-970 SP, Brazil.pt_BR Ueno,pt S M Sant'ana,ptário J A Saad,pté Antonio Rocha Gontijo,pt
dc.subjectAge Factorspt_BR
dc.subjectAnalysis Of Variancept_BR
dc.subjectBlotting, Westernpt_BR
dc.subjectCalcitonin Gene-related Peptidept_BR
dc.subjectGanglia, Spinalpt_BR
dc.subjectGene Expression Regulationpt_BR
dc.subjectMicroscopy, Immunoelectronpt_BR
dc.subjectRats, Inbred Shrpt_BR
dc.subjectRats, Inbred Wkypt_BR
dc.subjectReceptors, Neurokinin-1pt_BR
dc.subjectSubcellular Fractionspt_BR
dc.subjectSubstance Ppt_BR
dc.description.abstractThe kidneys play a pivotal role in the pathogenesis of essential hypertension because of a primary defect in renal hemodynamics and/or tubule hydro-saline handling that results in the retention of fluid and electrolytes. Previous studies have shown that increasing the renal pelvic pressure increased ipsilateral afferent renal nerve activity (ARNA), the ipsilateral renal pelvic release of substance P (SP) and the contralateral urinary sodium excretion in Wistar--Kyoto rats (WKy). However, spontaneously hypertensive rats (SHR) present an impaired renorenal reflex activity associated, partly, with a peripheral defect at the level of the sensory receptors in the renal pelvis. Furthermore, the renal pelvic administration of SP failed to increase ARNA in most of SHR at concentrations that produced marked increases in WKy. Since we have assessed the expression and localization of NK(1) receptor (NK(1)R), SP and calcitonin gene-related peptide (CGRP) in different dorsal root ganglia (DRG) cell subtypes and renal pelvis of 7- and 14-week-old SHR. The results of this study show increased SP and CGRP expression in the dorsal ganglia root cells of SHR compared to WKy rats. Additionally, there was a progressive, significant, age-dependent, decrease in NK(1)R expression on the membrane surface in SHR DRG cells and in the renal pelvis. In conclusion, the results of the present study suggest that the impaired activation of renal sensory neurons in SHR may be related to changes in the expression of neuropeptides and/or to a decreased presence of NK(1)R in DRG cells. Such abnormalities could contribute to the enhanced sodium retention and elevation of blood pressure seen in SHR.en
dc.relation.ispartofBrain Research. Molecular Brain Researchpt_BR
dc.relation.ispartofabbreviationBrain Res. Mol. Brain Res.pt_BR
dc.identifier.citationBrain Research. Molecular Brain Research. v. 138, n. 1, p. 35-44, 2005-Jul.pt_BR
dc.description.provenanceMade available in DSpace on 2015-11-27T13:02:04Z (GMT). No. of bitstreams: 1 pmed_15869822.pdf: 577250 bytes, checksum: 5793f15e43087af1ed6a0934c16512fe (MD5) Previous issue date: 2005en
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