Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196215
Type: Artigo de periódico
Title: Bone Marrow Progenitor Cells From Chemically Exposed Workers Display An Intrinsic Ability For Autonomous Proliferation.
Author: Valadares, Marize Campos
Bincoletto, Claudia
Oliveira, Sueli C
de Melo, Adriana
Saad, Sara T O
Queiroz, Mary L S
Abstract: In this study, the autonomous proliferation of bone marrow progenitor cells (CFU-C), a pathological phenomenon observed in many hematological abnormalities, was investigated in 31 individuals who had been diagnosed as having neutropenia. Of these subjects, 18 had been chronically exposed (range of exposure 5-30 years) to a variety of petroleum distillates. We observed that the group of exposed individuals presented higher numbers of autonomous CFU-C when compared with those unexposed subjects. In addition, follow-up data demonstrated that 20% of the exposed population (4 of the 18) developed malignant hematological diseases. The autonomous CFU-C obtained from all individuals studied was composed predominantly of macrophages. This suggests an involvement of these cells in the development of hematological abnormalities, probably as a result of increased production of chemical myelotoxic metabolites.
Subject: Adult
Aged
Bone Marrow Cells
Cell Proliferation
Hematopoietic Stem Cells
Humans
Middle Aged
Neutropenia
Occupational Exposure
Petroleum
Rights: fechado
Identifier DOI: 10.1081/IPH-51761
Address: http://www.ncbi.nlm.nih.gov/pubmed/15803866
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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