Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196148
Type: Artigo de periódico
Title: Poly(vinyl Alcohol) And Poly(vinyl Pyrrolidone) Blended Films For Local Nitric Oxide Release.
Author: Seabra, Amedea Barozzi
De Oliveira, Marcelo Ganzarolli
Abstract: The nitric oxide (NO) donor S-nitrosoglutathione (GSNO) was incorporated in solid polymeric films of poly(vinyl alcohol) (PVA), poly(vinyl pyrrolidone) (PVP) and blended PVA/PVP. These matrices were found to provide a great stabilization effect on the thermal decomposition of GSNO, leading to 8-16-fold reduction in the first-order rate constants of NO release, compared to aqueous GSNO solutions. PVA/PVP-GSNO released 90% of the NO supply, over a time period of 24h at 37 degrees C. Differential scanning calorimetry has confirmed the miscibility between the two polymeric components. Stress-strain analysis has shown an improvement of the mechanical property of PVA films in the PVA/PVP blend, which leads to an increase of 25% in the stress at break. Scanning electron microscopy has shown that the PVA/PVP-GSNO blend leads to a smooth coating of metallic surfaces. These properties, allied to the already known good biocompatibility of PVA and PVP, makes GSNO-containing PVA and PVA/PVP blend films good candidates for the local and controlled release of NO in target areas.
Subject: Coated Materials, Biocompatible
Delayed-action Preparations
Diffusion
Drug Carriers
Drug Delivery Systems
Elasticity
Kinetics
Materials Testing
Nitric Oxide
Polyvinyl Alcohol
Povidone
Surface Properties
Temperature
Tensile Strength
Rights: fechado
Identifier DOI: 10.1016/j.biomaterials.2003.10.035
Address: http://www.ncbi.nlm.nih.gov/pubmed/15020153
Date Issue: 2004
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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