Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Effect Of An Estrogen-deficient State And Its Therapy On Bone Loss Resulting From An Experimental Periodontitis In Rats.
Author: Duarte, Poliana Mendes
Gonçalves, Patricia Furtado
Sallum, Antonio Wilson
Sallum, Enilson Antonio
Casati, Marcio Zaffalon
Humberto Nociti, Francisco
Abstract: The aim of this study was to evaluate the impact of an estrogen-deficient state and its therapies (estrogen and calcitonin administration) upon bone loss resulting from an experimental periodontitis. Fifty-eight Wistar rats were divided into four groups: group 1 (n = 15): sham operated; group 2 (n = 15): ovariectomized; group 3 (n = 14): ovariectomized plus calcitonin administration; group 4 (n = 14): ovariectomized plus estrogen administration. Twenty-one days after ovariectomy or sham surgeries, the ligature was randomly placed. Sixty days later, the animals were killed and the specimens routinely processed. In addition, serum levels of alkaline phosphatase and calcium were assessed. Intergroup analysis revealed that an estrogen-deficient state significantly increased bone loss resulting from periodontitis and that such an effect could not be prevented either by estrogen or calcitonin administration (0.34 +/- 0.13, 0.65 +/- 0.06, 0.63 +/- 0.19, 0.67 +/- 0.28 for groups 1, 2, 3 and 4, respectively). Furthermore, an estrogen-deficient state presented a direct effect on the alveolar bone regardless of plaque accumulation and this effect may be significantly reduced by estrogen administration (p < 0.05). Serum analysis demonstrated a higher bone turnover for the animals with estrogen deficiency, and estrogen therapy restored bone metabolism. Estrogen administration may prevent the direct effect of an estrogen-deficient state on alveolar bone; however, neither estrogen nor calcitonin administration could prevent this effect when associated with a response to a plaque-related inflammatory process.
Subject: Alkaline Phosphatase
Alveolar Bone Loss
Analysis Of Variance
Dental Plaque
Estrogen Replacement Therapy
Image Processing, Computer-assisted
Matched-pair Analysis
Random Allocation
Rats, Wistar
Time Factors
Citation: Journal Of Periodontal Research. v. 39, n. 2, p. 107-10, 2004-Apr.
Rights: fechado
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_15009518.pdf235.58 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.