Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196142
Type: Artigo de periódico
Title: Effect Of An Estrogen-deficient State And Its Therapy On Bone Loss Resulting From An Experimental Periodontitis In Rats.
Author: Duarte, Poliana Mendes
Gonçalves, Patricia Furtado
Sallum, Antonio Wilson
Sallum, Enilson Antonio
Casati, Marcio Zaffalon
Humberto Nociti, Francisco
Abstract: The aim of this study was to evaluate the impact of an estrogen-deficient state and its therapies (estrogen and calcitonin administration) upon bone loss resulting from an experimental periodontitis. Fifty-eight Wistar rats were divided into four groups: group 1 (n = 15): sham operated; group 2 (n = 15): ovariectomized; group 3 (n = 14): ovariectomized plus calcitonin administration; group 4 (n = 14): ovariectomized plus estrogen administration. Twenty-one days after ovariectomy or sham surgeries, the ligature was randomly placed. Sixty days later, the animals were killed and the specimens routinely processed. In addition, serum levels of alkaline phosphatase and calcium were assessed. Intergroup analysis revealed that an estrogen-deficient state significantly increased bone loss resulting from periodontitis and that such an effect could not be prevented either by estrogen or calcitonin administration (0.34 +/- 0.13, 0.65 +/- 0.06, 0.63 +/- 0.19, 0.67 +/- 0.28 for groups 1, 2, 3 and 4, respectively). Furthermore, an estrogen-deficient state presented a direct effect on the alveolar bone regardless of plaque accumulation and this effect may be significantly reduced by estrogen administration (p < 0.05). Serum analysis demonstrated a higher bone turnover for the animals with estrogen deficiency, and estrogen therapy restored bone metabolism. Estrogen administration may prevent the direct effect of an estrogen-deficient state on alveolar bone; however, neither estrogen nor calcitonin administration could prevent this effect when associated with a response to a plaque-related inflammatory process.
Subject: Alkaline Phosphatase
Alveolar Bone Loss
Analysis Of Variance
Animals
Calcitonin
Calcium
Dental Plaque
Estradiol
Estrogen Replacement Therapy
Estrogens
Female
Image Processing, Computer-assisted
Ligation
Matched-pair Analysis
Ovariectomy
Periodontitis
Random Allocation
Rats
Rats, Wistar
Time Factors
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/15009518
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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