Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196094
Type: Artigo de periódico
Title: Resiniferatoxin For Detrusor Instability Refractory To Anticholinergics.
Author: Palma, Paulo C R
Thiel, Marcelo
Riccetto, Cássio L Z
Dambros, Miriam
Miyaoka, Ricardo
Netto, N Rodrigues
Abstract: We have evaluated the clinical and urodynamic effects of intravesical instillation of resiniferatoxin in patients with idiopathic detrusor instability refractory to anticholinergics. There were 30 women, median age 56 years old with detrusor instability for over 6 months and a history of anticholinergic use with no response or intolerable collateral effects. A 50 nM solution of resiniferatoxin was prepared for intravesical instillation. All patients were evaluated for urinary symptoms, as well as for urodynamic assessments before and 30 days after instillation. Tolerability was analyzed during the instillation. A clinical improvement was observed in 30% of the patients with urinary urgency and in 33% of the patients with urge-incontinence. The mean maximum cystometric capacity before application was 303.9 +/- 78.9 and after application 341 +/- 84.6. No significant difference was observed (p = 0.585). The mean maximum amplitude of the contractions diminished from 47.86 +/- 29.64 to 38.72 +/- 30.77 (p = 0.002). Resiniferatoxin, in this concentration, proved to be useful in a small percentage of patients regarding clinical detrusor instability. Maximum amplitude of the involuntary contractions was significantly reduced and in 33% patients the involuntary contractions disappeared. Further studies with different concentrations are recommended.
Subject: Adult
Aged
Aged, 80 And Over
Cholinergic Antagonists
Diterpenes
Drug Resistance
Female
Humans
Middle Aged
Muscle Hypertonia
Neurotoxins
Treatment Outcome
Urinary Bladder Diseases
Urinary Incontinence
Urination Disorders
Urodynamics
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/15707518
Date Issue: -1-Uns- -1
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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