Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/196047
Type: Artigo de periódico
Title: Evidence Of Memory Impairment In Asymptomatic Individuals With Hippocampal Atrophy.
Author: Alessio, Andréa
Kobayashi, Eliane
Damasceno, Benito P
Lopes-Cendes, Iscia
Cendes, Fernando
Abstract: Our objective was to investigate if MRI-determined hippocampal atrophy (HA) is associated with memory deficits independent of seizure frequency. We studied three groups of individuals: (1) 10 asymptomatic first-degree relatives of patients with familial mesial temporal lobe epilepsy (FMTLE), all of them with HA; (2) 14 patients with benign FMTLE, 9 with HA, and 5 with normal hippocampal volumes; and (3) 16 patients with refractory FMTLE, all but one with HA. HA was associated with lower scores on general memory (P=0.015), verbal memory (P=0.020), and delayed recall (P=0.028), even in those with no or few seizures in life. General linear model analyses showed that the interaction between seizure outcome and HA was associated with worse verbal memory (P=0.029), visual memory (P=0.022), and delayed recall (P=0.039) as compared with each of these factors independently. Our findings suggest that seizures and HA are independently associated with memory impairment.
Subject: Adolescent
Adult
Analysis Of Variance
Atrophy
Chi-square Distribution
Epilepsy, Temporal Lobe
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory Disorders
Middle Aged
Neuropsychological Tests
Rights: fechado
Identifier DOI: 10.1016/j.yebeh.2004.08.018
Address: http://www.ncbi.nlm.nih.gov/pubmed/15582848
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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