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Type: Artigo de periódico
Title: Influence Of Liposomal Local Anesthetics On Platelet Aggregation In Vitro.
Author: Pinto, Luciana M A
Pereira, Renata
de Paula, Eneida
de Nucci, Gilberto
Santana, Maria Helena A
Donato, José L
Abstract: We assessed the effect of local anesthetics (LA) from different families such as esters (benzocaine), linear aminoamides (lidocaine) and cyclic aminoamides (bupivacaine) on the platelet aggregation induced by ADP. Liposomal formulations of the three LA, prepared with egg phosphatidylcholine:cholesterol alpha-tocopherol, were also tested. The three LA were able to inhibit platelet aggregation induced by ADP, in the following order: bupivacaine > lidocaine > benzocaine. After encapsulation into liposomes the inhibitory effect increased for all anesthetics studied, showing that aggregation tests could be used to assess the toxicity of new drug formulations.
Subject: Adenosine Diphosphate
Anesthetics, Local
Blood Platelets
Dose-response Relationship, Drug
Drug Delivery Systems
Platelet Aggregation
Rights: fechado
Identifier DOI: 10.1081/LPR-120039697
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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