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Type: Artigo de periódico
Title: Protective Effect Of Bovine Milk Whey Protein Concentrate On The Ulcerative Lesions Caused By Subcutaneous Administration Of Indomethacin.
Author: Rosaneli, C F
Bighetti, A E
Antônio, M A
Carvalho, J E
Sgarbieri, V C
Abstract: The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive, or subchronic (10 days) administration of WPC prior to treatment with the ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P <.01). For the immobilization and cold model, maximum inhibition by WPC was 22.1%, and that for the reserpine model was 23.8%. In both models the inhibition was not significant (P >.05) compared with saline (negative control).
Subject: Animals
Anti-inflammatory Agents, Non-steroidal
Anti-ulcer Agents
Disease Models, Animal
Gastric Mucosa
Injections, Intraperitoneal
Injections, Subcutaneous
Milk Proteins
Random Allocation
Rats, Wistar
Stomach Ulcer
Rights: fechado
Identifier DOI: 10.1089/1096620041938722
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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