Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195939
Type: Artigo de periódico
Title: Frequency Of The 35delg Mutation In The Gjb2 Gene In Samples Of European, Asian, And African Brazilians.
Author: Oliveira, C A
Alexandrino, F
Abe-Sandes, K
Silva, W A
Maciel-Guerra, A T
Magna, L A
Sartorato, E L
Abstract: Mutations in the GJB2 gene are a major cause of congenital deafness. One specific mutation, the 35delG mutation, has accounted for most of the GJB2 mutations detected in European populations and is one of the most frequent disease mutations identified so far. We evaluated the frequency of the 35delG mutation in DNA samples from Brazilians of European, Asian, and African ancestry. All DNA samples were screened for the 35delG mutation using an allele-specific PCR. This study shows that the frequency of a common mutation (35delG) is significantly lower in non-European populations.
Subject: Africa
Asia
Brazil
Connexins
Dna Mutational Analysis
Deafness
Europe
Humans
Polymerase Chain Reaction
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/15359540
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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