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http://repositorio.unicamp.br/jspui/handle/REPOSIP/195932
Type: | Artigo de periódico |
Title: | Cell Death Evaluation In Benzo[a]pyrene-transformed Human Breast Epithelial Cells After Microcell-mediated Transfer Of Chromosomes 11 And 17. |
Author: | Mello, Maria Luiza S Barbisan, Luis Fernando Lareef, Mohamed H Russo, Jose Vidal, Benedicto de Campos |
Abstract: | The incidence of apoptosis and nuclear instability, including the incidence of catastrophic death, were investigated in benzo[a]pyrene (BP)-transformed human breast epithelial cells (BP1-E cell line) after microcell-mediated transfer of chromosomes 11 and 17. Since the introduction of normal chromosomes 11 and 17 into tumorigenic human breast BP1-E cells reverts some of these cells' characteristics (especially those affected by microsatellite instabilities and loss of heterozygosity) to those of parental non-transformed MCF-10F cells, it was expected that the cell death rates would also be affected by this treatment. The transfer of the mentioned chromosomes, especially chromosome 17, to tumorigenic BP1-E cells increased the apoptotic ratios and decreased the nuclear instability ratios, thus showing that the microsatellite instability and loss of heterozygosity induced by BP in these chromosomes of MCF-10F cells affect the control of cell death mechanisms. |
Subject: | Apoptosis Benzo(a)pyrene Breast Cell Line, Transformed Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 17 Epithelial Cells Humans |
Citation: | Mutation Research. v. 546, n. 1-2, p. 39-43, 2004-Feb. |
Rights: | fechado |
Identifier DOI: | |
Address: | http://www.ncbi.nlm.nih.gov/pubmed/14757191 |
Date Issue: | 2004 |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
Files in This Item:
File | Size | Format | |
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pmed_14757191.pdf | 102.96 kB | Adobe PDF | View/Open |
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