Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Hpv Dna Test And Pap Smear In Detection Of Residual And Recurrent Disease Following Loop Electrosurgical Excision Procedure Of High-grade Cervical Intraepithelial Neoplasia.
Author: Sarian, Luís Otávio
Derchain, Sophie F M
Andrade, Liliana A A
Tambascia, Júlia
Morais, Sirlei Siani
Syrjänen, Kari J
Abstract: We compared the performance of cervical cytology and HPV DNA test in detection of residual or recurrent disease following the treatment of cervical intraepithelial neoplasia (CIN) 2/3 with loop electrosurgical excision procedure (LEEP). A series of 107 women subjected to LEEP due to histologically confirmed CIN 2/3 between March 2001 and December 2002 were followed-up biannually until January 2004. Follow-up visits consisted of interview and gynecological examination including cervical cytology, hybrid capture II (HCII), and colposcopy. Patients presenting with abnormal colposcopy or high-grade squamous intraepithelial lesion (HSIL) smear were subjected to new excision procedure, and presence of histologically confirmed CIN 2/3 or higher was considered as residual or recurrent disease. Performance indicators were calculated for cytology and HCII assay in detecting residual or recurrent disease. Eleven (10.2%) women showed residual or recurrent disease during the follow-up. Considering HCII and Pap smear as stand-alone tests, both techniques showed similar sensitivity, detecting 100% of CIN 2/3 at the first follow-up visit. At the second follow-up visit, Pap smear showed better specificity and positive predictive value (PPV) than HCII, and both tests had fairly the same high negative predictive value (NPV) and sensitivity. The combined positive HCII and abnormal cytology had the same sensitivity as each of the tests alone, but specificity and PPV were significantly higher than those of single tests. When only one of the tests was positive, the sensitivity and the NPV of the combination remained the same, but its specificity and PPV were lower than that of the combined two positive tests and that of the individual test, at both follow-up visits. Both tests performed well in detecting residual or recurrent disease after LEEP and combination of the tests did not increase sensitivity of the single tests.
Subject: Adult
Cervical Intraepithelial Neoplasia
Cohort Studies
Dna, Viral
Follow-up Studies
Middle Aged
Neoplasm Recurrence, Local
Neoplasm, Residual
Papanicolaou Test
Reagent Kits, Diagnostic
Uterine Cervical Neoplasms
Vaginal Smears
Citation: Gynecologic Oncology. v. 94, n. 1, p. 181-6, 2004-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.ygyno.2004.03.036
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_15262139.pdf109.56 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.