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Type: Artigo de periódico
Title: Cytotoxicity Of Tamoxifen In Normal And Tumoral Cell Lines And Its Ability To Induce Cellular Transformation In Vitro.
Author: Petinari, Leandro
Kohn, Luciana Konecny
de Carvalho, João Ernesto
Genari, Selma Candelária
Abstract: Tamoxifen (TAM) is a non-steroidal anti-estrogen used to treat patients with estrogen receptor-positive breast cancer and as a chemopreventive agent against breast cancer in high risk pre- and post-menopausal women. However, recent studies have shown that tamoxifen causes endometrial and hepatic cancer. In this study, we examined the effects of tamoxifen (5, 10, 25 and 50 microM) on the growth and proliferation of nine tumoral cell lines (UACC62, MCF-7, NCI-460, K-562, OVCAR-03, PC-03, HT-29, 786-0, NCI-ADR) and non-tumoral cell lines (3T3, V79, MDCK, VERO). Chinese hamster lung fibroblasts (V79) were the most sensitive lineage to tamoxifen, with 21.6% of the cells showing apoptosis at 50 microM TAM. Microscopic analysis showed that, the cellular transformation caused by TAM in V79 cells was similar to that seen with 7,12-dimethylbenz(a)anthracene, thus indicating the carcinogenicity of TAM.
Subject: Animals
Antineoplastic Agents, Hormonal
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic
Estrogen Antagonists
Citation: Cell Biology International. v. 28, n. 7, p. 531-9, 2004.
Rights: fechado
Identifier DOI: 10.1016/j.cellbi.2004.04.008
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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