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Type: Artigo de periódico
Title: Short Synthesis Of The 6,6-spiroketal Cores Of Spirofungins A And B.
Author: Dias, Luiz C
de Oliveira, Luciana G
Abstract: [reaction: see text] Initial efforts toward the total synthesis of the antifungal antibiotics spirofungins A and B are reported. A short and efficient synthesis of the C9-C20 6,6-spiroketal fragments of both compounds is described. This asymmetric approach uses a very efficient alkylation of a lithiated N,N-dimethylhydrazone followed by spiroketal formation under acidic conditions.
Subject: Alkylation
Antifungal Agents
Combinatorial Chemistry Techniques
Molecular Structure
Spiro Compounds
Rights: fechado
Identifier DOI: 10.1021/ol0491078
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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