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Type: Artigo de periódico
Title: Glucocorticoid Receptor And Beta-adrenoceptor Expression In Epididymal Adipose Tissue From Stressed Rats.
Author: Farias-Silva, Elisangela
dos Santos, Iraídes Nunes
Corezola do Amaral, Maria Esméria
Grassi-Kassisse, Dora Maria
Spadari-Bratfisch, Regina Celia
Abstract: Adipocytes isolated from epididymal adipose tissue of foot-shock stressed rats are supersensitive to isoprenaline and subsensitive to norepinephrine. These alterations are probably mediated by a stress-induced increase in plasma corticosterone levels. We investigated whether foot-shock stress modifies the expression of glucocorticoid receptors (GRs) and beta-adrenergic protein receptors (beta-ARs) in epididymal adipose tissue from rats submitted to one daily foot-shock session on three consecutive days. This stress protocol caused decreases in GR, beta(1)-AR, and beta(3)-AR protein levels, but caused an increase in beta(2)-AR. These results confirm and support previous functional studies. The alterations in protein expression may be modulated by the high corticosterone levels that downregulate the glucocorticoid receptor.
Subject: Adipose Tissue
Rats, Wistar
Receptors, Adrenergic, Beta
Receptors, Glucocorticoid
Stress, Physiological
Rights: fechado
Identifier DOI: 10.1196/annals.1296.040
Date Issue: 2004
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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