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Type: Artigo de periódico
Title: Modulation Of Gastrin And Epidermal Growth Factor By Pyrrolizidine Alkaloids Obtained From Senecio Brasiliensis In Acute And Chronic Induced Gastric Ulcers.
Author: Toma, Walber
Trigo, José Roberto
Bensuaski de Paula, Ana Cláudia
Monteiro Souza Brito, Alba Regina
Abstract: We investigated the antiulcerogenic activity of pyrrolizidine alkaloids (PAs) integerrimine, retrorsine, senecionine, usaramine and seneciplhylline, an alkaloidal extract obtained from Senecio brasiliensis. The PA extract demonstrated significantly activity in both, acute and chronic gastric ulcers on rats. The effects of PA extract were dose dependent. The mechanisms implicated on this activity were evaluated by determination of gastrin plasma levels in rats subjected to the acute treatment with PA extract and by expression of mRNA of Epidermal Growth Factor (EGF) after chronic treatment with this extract. The results showed that the PA extract increased both the levels of gastrin and the expression of EGF on these animals. Moreover, the histological examinations showed a reduction of exfoliation of superficial cells, hemorrhages and blood cell infiltration. We concluded that the PAs showed an important and qualitative antiulcerogenic activity mediated by increase in gastrin secretion and mRNA expression of EGF.
Subject: Animals
Dose-response Relationship, Drug
Epidermal Growth Factor
Plant Extracts
Pyrrolizidine Alkaloids
Stomach Ulcer
Citation: Canadian Journal Of Physiology And Pharmacology. v. 82, n. 5, p. 319-25, 2004-May.
Rights: fechado
Identifier DOI: 10.1139/y04-023
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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