Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195818
Type: Artigo de periódico
Title: Tissue Alterations In The Guinea Pig Lateral Prostate Following Antiandrogen Flutamide Therapy.
Author: Cordeiro, Renato Simões
Scarano, Wellerson Rodrigo
Góes, Rejane Maira
Taboga, Sebastião Roberto
Abstract: The flutamide antiandrogenic effects on the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study. Daily-treated group animals received flutamide subcutaneous injection at a dose of 10 mg/Kg body weight for 10 days. The control group animals received a pharmacological vehicle under the same conditions. The lateral prostate was removed, fixed and processed for light and transmission electron microscopy. The results revealed an increase of the acinus diameter in the treated puberal animals and straitness in the stromal compartment around the acini. The epithelial cells exhibited cubic phenotype. In the post-puberal and adult animals, a decrease of the acinus diameter was observed, as well as an increase of the smooth muscle layer and presence of the folds at epithelium. The ultrastructural evaluation of the secretory cells in the treated group demonstrated endomembrane enlargement, mainly in the rough endoplasmic reticulum and Golgi apparatus. In addition, a decrease of the microvilli and alterations in the distribution patterns and density of the stromal fibrillar components were observed. In conclusion, the flutamide treatment exerts tissue effects on the lateral prostate, promoting stroma/epithelium alterations.
Subject: Age Factors
Androgen Antagonists
Animals
Cell Size
Endoplasmic Reticulum
Epithelial Cells
Flutamide
Golgi Apparatus
Guinea Pigs
Male
Microscopy, Electron
Microvilli
Myocytes, Smooth Muscle
Prostate
Sexual Maturation
Stromal Cells
Citation: Biocell : Official Journal Of The Sociedades Latinoamericanas De Microscopía Electronica ... Et. Al. v. 28, n. 1, p. 21-30, 2004-Apr.
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/15176738
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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