Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195808
Type: Artigo de periódico
Title: Primary Nerve Repair By Muscle Autografts Prepared With Local Anesthetic.
Author: Neto, Humberto Santo
Pertille, Adriana
Teodori, Rosana Marcher
Somazz, Marco Cesar
Marques, Maria Julia
Abstract: We evaluated the usefulness of muscle autografts obtained immediately after graft preparation with lidocaine injections for primary nerve repair. The right sciatic nerve of adult Wistar rats was sectioned, and muscle grafts obtained 15 min or 24 h after lidocaine injection were used to repair a gap 1.5 cm long. Axon and fiber diameters, as well as myelin thickness, decreased to similar extents for grafts of both time intervals. The G-ratios in the distal stumps of both groups were not different from controls, indicating that regenerated axons had a proper level of myelination. The ultrastructural appearance of the neuromuscular junctions was similar to that of normal samples. These results indicate that there are no restrictions to the use of a muscle graft for primary nerve repair, immediately after lidocaine injection, since the nerve regeneration was comparable to that observed with this type of graft used 24 h after being prepared.
Subject: Anesthesia, Local
Animals
Disease Models, Animal
Female
Lidocaine
Male
Microscopy, Confocal
Muscle Fibers, Skeletal
Muscle, Skeletal
Nerve Regeneration
Rats
Rats, Wistar
Reference Values
Sciatic Nerve
Sensitivity And Specificity
Tissue Transplantation
Transplantation, Autologous
Rights: fechado
Identifier DOI: 10.1002/micr.20046
Address: http://www.ncbi.nlm.nih.gov/pubmed/15160376
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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