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dc.typeArtigo de periódicopt_BR
dc.titleThe Pharmacological Effect Of Bothrops Neuwiedii Pauloensis (jararaca-pintada) Snake Venom On Avian Neuromuscular Transmission.pt_BR
dc.contributor.authorBorja-Oliveira, C Rpt_BR
dc.contributor.authorDurigon, A Mpt_BR
dc.contributor.authorVallin, A C Cpt_BR
dc.contributor.authorToyama, M Hpt_BR
dc.contributor.authorSouccar, Cpt_BR
dc.contributor.authorMarangoni, Spt_BR
dc.contributor.authorRodrigues-Simioni, Lpt_BR
unicamp.authorC R Borja-Oliveira, Departamento de Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil. simioni@obelix.unicamp.brpt_BR M Durigon,pt C C Vallin,pt H Toyama,pt Souccar,pt Marangoni,pt Rodrigues-Simioni,pt
dc.subjectCrotalid Venomspt_BR
dc.subjectDose-response Relationship, Drugpt_BR
dc.subjectMuscle Contractionpt_BR
dc.subjectMuscle, Skeletalpt_BR
dc.subjectNeuromuscular Junctionpt_BR
dc.subjectPotassium Chloridept_BR
dc.subjectTime Factorspt_BR
dc.description.abstractThe neuromuscular effects of Bothrops neuwiedii pauloensis (jararaca-pintada) venom were studied on isolated chick biventer cervicis nerve-muscle preparations. Venom concentrations of 5-50 micro g/ml produced an initial inhibition and a secondary increase of indirectly evoked twitches followed by a progressive concentration-dependent and irreversible neuromuscular blockade. At venom concentrations of 1-20 micro g/ml, the responses to 13.4 mM KCl were inhibited whereas those to 110 micro M acetylcholine alone and cumulative concentrations of 1 micro M to 10 mM were unaffected. At venom concentrations higher than 50 micro g/ml, there was pronounced muscle contracture with inhibition of the responses to acetylcholine, KCl and direct stimulation. At 20-24 degrees C, the venom (50 g/ml) produced only partial neuromuscular blockade (30.7 +/- 8.0%, N = 3) after 120 min and the initial inhibition and the secondary increase of the twitch responses caused by the venom were prolonged and pronounced and the response to KCl was unchanged. These results indicate that B.n. pauloensis venom is neurotoxic, acting primarily at presynaptic sites, and that enzyme activity may be involved in this pharmacological action.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 36, n. 5, p. 617-24, 2003-May.pt_BR
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