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Type: Artigo de periódico
Title: Natural Killer Cell Activity, Lymphocyte Proliferation, And Cytokine Profile In Tumor-bearing Mice Treated With Mapa, A Magnesium Aggregated Polymer From Aspergillus Oryzae.
Author: Justo, G Z
Durán, N
Queiroz, M L S
Abstract: The present study examined the effects of MAPA, an antitumor aggregated polymer of protein magnesium ammonium phospholinoleate-palmitoleate anhydride, isolated from Aspergillus oryzae, on concanavalin A (Con A)-induced spleen cell proliferation, cytokine production and on natural killer (NK) cell activity in Ehrlich ascites tumor-bearing mice. The Ehrlich ascites tumor (EAT) growth led to diminished mitogen-induced expansion of spleen cell populations and total NK activity. This was accompanied by striking spleen enlargement, with a marked increase in total cell counts. Moreover, a substantial enhancement in IL-10 levels, paralleled by a significant decrease in IL-2 was observed, while production of IL-4 and interferon-gamma (IFN-gamma) was not altered. Treatment of mice with 5 mg/kg MAPA for 7 days promoted spleen cell proliferation, IL-2 production and NK cell activity regardless of tumor outgrowth. In addition, MAPA treatment markedly enhanced IFN-gamma levels and reduced IL-10 production relative to EAT mice. A 35% reduction in splenomegaly with normal number of nucleated cells was also found. Altogether, our results suggest that MAPA directly and/or indirectly modulates immune cell activity, and probably disengages tumor-induced suppression of these responses. Clearly, MAPA has an impact and may delay tumor outgrowth through immunotherapeutic mechanisms.
Subject: Animals
Antineoplastic Agents
Aspergillus Oryzae
Carcinoma, Ehrlich Tumor
Cell Proliferation
Cells, Cultured
Concanavalin A
Killer Cells, Natural
Linoleic Acids
Mice, Inbred Balb C
Organophosphorus Compounds
Time Factors
Tumor Escape
Citation: Immunopharmacology And Immunotoxicology. v. 25, n. 3, p. 305-19, 2003-Aug.
Rights: fechado
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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