Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195600
Type: Artigo de periódico
Title: Thalamic Dysfunction In Juvenile Myoclonic Epilepsy: A Proton Mrs Study.
Author: Mory, Susana B
Li, Li M
Guerreiro, Carlos A M
Cendes, Fernando
Abstract: To investigate neuronal dysfunction in the thalami of patients with juvenile myoclonic epilepsy (JME) by using proton magnetic resonance spectroscopy (MRS). We performed single-voxel proton MRS over the right and the left thalami of 10 consecutive patients (five women) with JME (mean age, 31.6 years) and 10 age-matched healthy volunteers (five men). All patients had seizure onset in late childhood-teenage, normal neurologic examination, typical EEG of JME, and normal high-resolution MR imaging (MRI). We determined ratios of N-acetylaspartate (NAA) over creatine-phosphocreatine (Cr). Values <2 standard deviations from controls were considered abnormal. We performed analysis of variance to evaluate group differences. Group analysis showed that thalami NAA/Cr ratios were significantly decreased in JME patients (left side, 1.58 +/- 0.26; right side, 1.5 +/- 0.15) as compared with controls (left side, 1.98 +/- 0.18; right side, 1.88 +/- 0.15; p = 0.001 and p = 0.007, respectively). Individual analysis showed that nine of the 10 patients had abnormal NAA/Cr in at least one of the thalami. This study shows evidence of neuronal dysfunction in the thalami of patients with JME, which may have relevance for the mechanisms of seizure generation in this form of generalized epilepsy.
Subject: Adolescent
Adult
Analysis Of Variance
Aspartic Acid
Creatine
Dominance, Cerebral
Energy Metabolism
Female
Humans
Image Processing, Computer-assisted
Magnetic Resonance Spectroscopy
Male
Myoclonic Epilepsy, Juvenile
Phosphocreatine
Reference Values
Thalamic Diseases
Thalamus
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/14636347
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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