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Type: Artigo de periódico
Title: Effects Of Ethanol On Deep Pain Evoked By Formalin Injected In Tmj Of Rat.
Author: Gameiro, Gustavo Hauber
Arthuri, Mariana Trevisani
Tambeli, Cláudia Herrera
de Arruda Veiga, Maria Cecília Ferraz
Abstract: It has been reported that ethanol can alter nociceptive sensitivity from superficial tissues, such as skin and subcutaneous region. However, the influence of ethanol on deep pain conditions is not understood. The aim of this study was to demonstrate the acute, chronic and ethanol withdrawal effects on nociceptive behavioral responses induced by the injection of formalin into the temporomandibular joint (TMJ) region of rats. In experiment 1, rats were injected with ethanol (2,5 g/Kg, i.p.) or an equal volume of saline 15 min before the administration of formalin (1.5%) into the TMJ. Rats pretreated with ethanol showed a decrease in nociceptive behavioral responses. In experiment 2, rats were given an ethanol solution (6.5%) or tap water to drink for 4 and 10 days. On day 4, the animals (ethanol group) showed amounts of analgesia when submitted to the TMJ formalin test. Tolerance to the antinociceptive effects was observed on day 10. Behavioral hyperalgesia was verified 12 hr after withdrawal in another group that drank ethanol for 10 days. These results show that ethanol can affect the nociceptive responses related to deep pain evoked by the TMJ formalin test.
Subject: Analgesics
Behavior, Animal
Central Nervous System Depressants
Disease Models, Animal
Drug Interactions
Injections, Intraperitoneal
Pain Measurement
Pain Threshold
Rats, Wistar
Substance Withdrawal Syndrome
Temporomandibular Joint
Water Supply
Rights: fechado
Identifier DOI: 
Date Issue: 2003
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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