Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195568
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA Novel Sunscreen Agent Having Antimelanoma Activity.pt_BR
dc.contributor.authorNogueira, Marisa Apt_BR
dc.contributor.authorMagalhães, Eva Gpt_BR
dc.contributor.authorMagalhães, Aderbal Fpt_BR
dc.contributor.authorBiloti, Débora Npt_BR
dc.contributor.authorLaverde, Antoniopt_BR
dc.contributor.authorPessine, Francisco B Tpt_BR
dc.contributor.authorCarvalho, João Ept_BR
dc.contributor.authorKohn, Luciana Kpt_BR
dc.contributor.authorAntônio, Márcia Apt_BR
dc.contributor.authorMarsaioli, Anita Jpt_BR
unicamp.authorMarisa A Nogueira, Instituto de Química, Universidade Estadual de Campinas, CP 6154, SP, 13083-970 Campinas, Brazil.pt_BR
unicamp.author.externalEva G Magalhães,pt
unicamp.author.externalAderbal F Magalhães,pt
unicamp.author.externalDébora N Biloti,pt
unicamp.author.externalAntonio Laverde,pt
unicamp.author.externalFrancisco B T Pessine,pt
unicamp.author.externalJoão E Carvalho,pt
unicamp.author.externalLuciana K Kohn,pt
unicamp.author.externalMárcia A Antônio,pt
unicamp.author.externalAnita J Marsaioli,pt
dc.subjectAntineoplastic Agentspt_BR
dc.subjectBenzoatespt_BR
dc.subjectCell Line, Tumorpt_BR
dc.subjectChalconespt_BR
dc.subjectDose-response Relationship, Drugpt_BR
dc.subjectDrug Screening Assays, Antitumorpt_BR
dc.subjectHumanspt_BR
dc.subjectMelanomapt_BR
dc.subjectSkin Neoplasmspt_BR
dc.subjectSunscreening Agentspt_BR
dc.description.abstractA novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation.en
dc.relation.ispartofFarmaco (società Chimica Italiana : 1989)pt_BR
dc.relation.ispartofabbreviationFarmacopt_BR
dc.date.issued2003-Novpt_BR
dc.identifier.citationFarmaco (società Chimica Italiana : 1989). v. 58, n. 11, p. 1163-9, 2003-Nov.pt_BR
dc.language.isoengpt_BR
dc.description.volume58pt_BR
dc.description.firstpage1163-9pt_BR
dc.rightsfechadopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0014-827Xpt_BR
dc.identifier.doipt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/14572867pt_BR
dc.date.available2015-11-27T12:52:31Z-
dc.date.accessioned2015-11-27T12:52:31Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:52:31Z (GMT). No. of bitstreams: 1 pmed_14572867.pdf: 566857 bytes, checksum: e4bd761ad4ed6f70d5ac6c04ea2dfeb2 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195568-
dc.identifier.idPubmed14572867pt_BR
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