Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195568
Type: Artigo de periódico
Title: A Novel Sunscreen Agent Having Antimelanoma Activity.
Author: Nogueira, Marisa A
Magalhães, Eva G
Magalhães, Aderbal F
Biloti, Débora N
Laverde, Antonio
Pessine, Francisco B T
Carvalho, João E
Kohn, Luciana K
Antônio, Márcia A
Marsaioli, Anita J
Abstract: A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation.
Subject: Antineoplastic Agents
Benzoates
Cell Line, Tumor
Chalcones
Dose-response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Melanoma
Skin Neoplasms
Sunscreening Agents
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/14572867
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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