Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195537
Type: Artigo de periódico
Title: Crotapotin Induced Modification Of T Lymphocyte Proliferative Response Through Interference With Pge2 Synthesis.
Author: Garcia, Flavia
Toyama, Marcos H
Castro, Fabiano R
Proença, Patrícia L
Marangoni, Sergio
Santos, Leonilda M B
Abstract: The immunosuppressive property has been demonstrated for the venom of the Crotalus durissus terrificus. Using a simple, novel method for obtaining crotapotin and phospholipase A2 isoforms from venom, it was possible to demonstrate that the addition of crotapotin to cultures of isolated lymphocytes resulted in a significant inhibition of the cellular proliferative response to Concanavalin A. This reduction in blastogenic response of lymphocytes is accompanied by a significant increase in the production of PGE2 by macrophages. This effect on the innate immune response suggests that this compound may modify the subsequent adaptative immune response.
Subject: Animals
Crotoxin
Dinoprostone
Enzyme Inhibitors
Female
Immunity, Cellular
Immunosuppressive Agents
In Vitro Techniques
Lymphocyte Activation
Macrophages
Mice
Mice, Inbred Strains
Phospholipases A
Phospholipases A2
T-lymphocytes
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/14505945
Date Issue: 2003
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_14505945.pdf201.84 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.