Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195516
Type: Artigo de periódico
Title: Evaluation Of The Analgesic And Antiedematogenic Activities Of Quassia Amara Bark Extract.
Author: Toma, W
Gracioso, J S
Hiruma-Lima, C A
Andrade, F D P
Vilegas, W
Souza Brito, A R M
Abstract: We evaluated the possible antiedematogenic, antinociceptive and/or sedative effects of four different extracts obtained from the bark of Quassia amara namely, 70% ethanol (70EtOH), 100% ethanol (100EtOH), dichloromethane (DCM) and hexane extracts (HEX). The oral administration (100, 250 and 500 mg/kg) of these extracts did not show significant effects in any experiment. However, when administered intraperitoneally, the HEX extract decreased the paw edema induced by carrageenan, showed antinociceptive effects on the hot-plate test and on acetic acid-induced writhing, and showed sedative effects on pentobarbital-induced sleep. Naloxone did not reverse the antinociceptive effect of this extract. In conclusion, although the mechanisms are uncertain, the results demonstrated that these effects are apparently related to sedative and muscle relaxant or psychomimetic activities of the HEX extract of the plant.
Subject: Administration, Oral
Analgesics
Analysis Of Variance
Animals
Anti-inflammatory Agents
Carrageenan
Dose-response Relationship, Drug
Edema
Hypnotics And Sedatives
Injections, Intraperitoneal
Male
Mice
Phytotherapy
Plant Bark
Plant Extracts
Quassia
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/12576198
Date Issue: 2003
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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