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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffect Of Intracerebroventricularly Injected Insulin On Urinary Sodium Excretion By Cerebroventricular Streptozotocin-treated Rats.pt_BR
dc.contributor.authorMacedo, R Fpt_BR
dc.contributor.authorFurlan, F Cpt_BR
dc.contributor.authorMarshall, P Spt_BR
dc.contributor.authorMichelotto, J Bpt_BR
dc.contributor.authorGontijo, J A Rpt_BR
unicamp.authorR F Macedo, Disciplina de Medicina Interna, Laborat rio Balanço Hidro-Salino, Núcleo de Medicina e Cirurgia Experimental, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.pt_BR
unicamp.author.externalF C Furlan,pt
unicamp.author.externalP S Marshall,pt
unicamp.author.externalJ B Michelotto,pt
unicamp.author.externalJ A R Gontijo,pt
dc.subjectAnimalspt_BR
dc.subjectAntibiotics, Antineoplasticpt_BR
dc.subjectBrainpt_BR
dc.subjectGlomerular Filtration Ratept_BR
dc.subjectInjections, Intraventricularpt_BR
dc.subjectInjections, Subcutaneouspt_BR
dc.subjectInsulinpt_BR
dc.subjectMalept_BR
dc.subjectNatriuresispt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectReceptor, Insulinpt_BR
dc.subjectSignal Transductionpt_BR
dc.subjectStreptozocinpt_BR
dc.subjectTime Factorspt_BR
dc.description.abstractRecent evidence suggests that insulin may influence many brain functions. It is known that intracerebroventricular (icv) injection of nondiabetogenic doses of streptozotocin (STZ) can damage insulin receptor signal transduction. In the present study, we examined the functional damage to the brain insulin receptors on central mechanisms regulating glomerular filtration rate and urinary sodium excretion, over four periods of 30 min, in response to 3 microl insulin or 0.15 NaCl (vehicle) injected icv in STZ-treated freely moving Wistar-Hannover rats (250-300 g). The icv cannula site was visually confirmed by 2% Evans blue infusion. Centrally administered insulin (42.0 ng/ micro l) increased the urinary output of sodium (from 855.6 85.1 to 2055 310.6 delta%/min; N = 11) and potassium (from 460.4 100 to 669 60.8 delta%/min; N = 11). The urinary sodium excretion response to icv insulin microinjection was markedly attenuated by previous central STZ (100 micro g/3 micro l) administration (from 628 45.8 to 617 87.6 delta%/min; N = 5) or by icv injection of a dopamine antagonist, haloperidol (4 micro g/3 micro l) (from 498 +/- 39.4 to 517 +/- 73.2 delta%/min; N = 5). Additionally, insulin-induced natriuresis occurred by increased post-proximal tubule sodium rejection, despite an unchanged glomerular filtration rate. Excluding the possibility of a direct action of STZ on central insulin receptor-carrying neurons, the current data suggest that the insulin-sensitive response may be processed through dopaminergic D1 receptors containing neuronal pathways.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.date.issued2003-Seppt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 36, n. 9, p. 1193-9, 2003-Sep.pt_BR
dc.language.isoengpt_BR
dc.description.volume36pt_BR
dc.description.firstpage1193-9pt_BR
dc.rightsabertopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.doipt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/12937785pt_BR
dc.date.available2015-11-27T12:52:23Z-
dc.date.accessioned2015-11-27T12:52:23Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:52:23Z (GMT). No. of bitstreams: 1 pmed_12937785.pdf: 459311 bytes, checksum: 77b82148a1c0aee6eb71031780e869ee (MD5) Previous issue date: 2003en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195501-
dc.identifier.idPubmed12937785pt_BR
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