Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195480
Type: Artigo de periódico
Title: Expression Of P53, C-erbb-2, Ki-67, And Cd34 In Granulosa Cell Tumor Of The Ovary.
Author: Kusamura, S
Derchain, S
Alvarenga, M
Gomes, C P
Syrjänen, K J
Andrade, L A L A
Abstract: The purpose of this study is to investigate the expression of p53, c-erbB-2, Ki-67, and angiogenic activity and their correlation with the clinicopathologic characteristics in a series of granulosa cell tumors of the ovary (GCTO). Eighteen GCTO cases assisted at the Department of Obstetrics and Gynecology, School of Medical Science, UNICAMP, after diagnostic confirmation by three pathologists, were submitted to immunohistochemistry for assessment of p53, c-erbB-2, Ki-67, and CD34 expressions. The mean tumor size was 13 cm (range: 4-30 cm). Six (33%) cases presented with extraovarian disease. Thirteen (72%) cases presented some solid diffuse or sarcomatoid pattern and six (33%) moderate or strong atypia. Fourteen cases presented </=2 mitoses/10 HPF. Thirteen cases were focally positive for Ki-67. The mean Ki-67 proliferative index was 1.0%. One case presented positive expression for mutant p53 but all cases were negative for c-erbB-2 expression. The mean microvascular density was 28.9/mm2 (range: 0-50). No significant correlations could be established between the biologic markers and clinicopathologic variables. GCTO showed a markedly low rate of immunohistochemical staining for p53 or c-erbB-2 overexpression/amplification, as well as low proliferative and angiogenic activities. Further studies are urgently needed to elaborate the factors responsible for the highly unpredictable clinical course of GCTO.
Subject: Adolescent
Adult
Aged
Aged, 80 And Over
Antigens, Cd34
Biopsy, Needle
Disease-free Survival
Female
Genes, P53
Granulosa Cell Tumor
Humans
Immunohistochemistry
Ki-67 Antigen
Middle Aged
Ovarian Neoplasms
Prognosis
Receptor, Erbb-2
Risk Assessment
Sampling Studies
Sensitivity And Specificity
Survival Analysis
Tumor Markers, Biological
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/12911721
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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