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Type: Artigo de periódico
Title: Outcome Of Surgical Treatment In Familial Mesial Temporal Lobe Epilepsy.
Author: Kobayashi, Eliane
D'Agostino, Maria Daniela
Lopes-Cendes, Iscia
Andermann, Eva
Dubeau, François
Guerreiro, Carlos A M
Schenka, André A
Queiroz, Luciano S
Olivier, André
Cendes, Fernando
Andermann, Frederick
Abstract: To describe postoperative outcome in patients with familial mesial temporal lobe epilepsy (FMTLE). We studied FMTLE patients who underwent surgical treatment for refractory seizures. FMTLE was defined when at least two individuals in a family had a clinical EEG diagnosis of MTLE. Preoperative investigation included magnetic resonance imaging (MRI), interictal/ictal EEGs, and neuropsychological evaluation. We used Engel's classification for postoperative outcome. To date, 20 FMTLE patients have been operated on, with 1.6 to 9.8 years of follow-up (mean, 5.5 years). Hippocampal atrophy (HA) and other signs of mesial temporal sclerosis (MTS) were present in 18 patients (15 unilateral). Seizures were recorded in 19 patients. Seventeen (85%) patients are in class I. Two patients had normal hippocampal volumes (HcV): one (5%) is in class II and the other (5%) in class IV (extratemporal seizures developed after surgery). One (5%) patient had bilateral HA and is in class III. Qualitative histopathology showed MTS with different degrees of severity. Refractory FMTLE patients have good surgical outcome when unilateral or clearly asymmetric HA is identified. Preoperative investigation should be the same as that in patients with sporadic refractory MTLE.
Subject: Adult
Anterior Temporal Lobectomy
Dominance, Cerebral
Epilepsy, Temporal Lobe
Follow-up Studies
Middle Aged
Temporal Lobe
Treatment Outcome
Citation: Epilepsia. v. 44, n. 8, p. 1080-4, 2003-Aug.
Rights: fechado
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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