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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCholesteryl Ester Transfer Protein Expression Is Down-regulated In Hyperinsulinemic Transgenic Mice.pt_BR
dc.contributor.authorBerti, J Apt_BR
dc.contributor.authorCasquero, A Cpt_BR
dc.contributor.authorPatricio, P Rpt_BR
dc.contributor.authorBighetti, E J Bpt_BR
dc.contributor.authorCarneiro, E Mpt_BR
dc.contributor.authorBoschero, A Cpt_BR
dc.contributor.authorOliveira, H C Fpt_BR
unicamp.authorJ A Berti, Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, 13083-970, SP, Brazil.pt_BR
unicamp.author.externalA C Casquero,pt
unicamp.author.externalP R Patricio,pt
unicamp.author.externalE J B Bighetti,pt
unicamp.author.externalE M Carneiro,pt
unicamp.author.externalA C Boschero,pt
unicamp.author.externalH C F Oliveira,pt
dc.subjectAnimalspt_BR
dc.subjectBody Compositionpt_BR
dc.subjectCarrier Proteinspt_BR
dc.subjectCholesterol Ester Transfer Proteinspt_BR
dc.subjectCholesterol Esterspt_BR
dc.subjectDown-regulationpt_BR
dc.subjectGene Expression Regulationpt_BR
dc.subjectGlucosept_BR
dc.subjectGlycoproteinspt_BR
dc.subjectHumanspt_BR
dc.subjectHyperinsulinismpt_BR
dc.subjectInsulinpt_BR
dc.subjectLipoproteinspt_BR
dc.subjectLiverpt_BR
dc.subjectMicept_BR
dc.subjectMice, Transgenicpt_BR
dc.subjectRna, Messengerpt_BR
dc.description.abstractCholesteryl ester transfer protein (CETP) mediates cholesteryl ester (CE) and triglyceride redistribution among plasma lipoproteins. In this work, we investigated whether varying levels of insulin regulate the CETP expression in vivo. Insulin deficiency [streptozotocin (STZ) injection], and hyperinsulinemia (insulin injections, 14 days) were induced in transgenic mice expressing a human CETP minigene flanked by its natural regulatory sequences. Glucose supplementation was provided to the hyperinsulinemic group (INS+GLUC) and to an extra group of mice (GLUC). In the STZ group, endogenous CE transfer rate, plasma CETP, and hepatic CETP mRNA levels were enhanced 3.0-, 1.5-, and 2.5-fold, respectively, as compared with controls. Insulin replacement in STZ mice normalized their glycemia and liver mRNA levels. Higher plasma CETP levels were observed in GLUC mice, which were decreased in INS+GLUC mice. Hepatic CETP mRNA was not altered in GLUC mice and was reduced by one-third in INS+GLUC mice. These results show that: 1) STZ treatment increases CETP plasma levels and liver mRNA expression; 2) diet glucose supplementation increases plasma CETP levels but does not change liver mRNA abundance; and 3) daily insulin injections blunt the glucose-stimulated CETP expression by reducing its liver mRNA levels. These data suggest that insulin down-regulates CETP gene expression.en
dc.relation.ispartofJournal Of Lipid Researchpt_BR
dc.relation.ispartofabbreviationJ. Lipid Res.pt_BR
dc.date.issued2003-Octpt_BR
dc.identifier.citationJournal Of Lipid Research. v. 44, n. 10, p. 1870-6, 2003-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume44pt_BR
dc.description.firstpage1870-6pt_BR
dc.rightsfechadopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0022-2275pt_BR
dc.identifier.doi10.1194/jlr.M300036-JLR200pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/12867535pt_BR
dc.date.available2015-11-27T12:52:17Z-
dc.date.accessioned2015-11-27T12:52:17Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:52:17Z (GMT). No. of bitstreams: 1 pmed_12867535.pdf: 353794 bytes, checksum: 77136985914814db24a9936b7b5fdbf5 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195451-
dc.identifier.idPubmed12867535pt_BR
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