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Type: Artigo de periódico
Title: Cerebellar Volume And Long-term Use Of Phenytoin.
Author: De Marcos, Felipe Antonio
Ghizoni, Enrico
Kobayashi, Elaine
Li, Li Min
Cendes, Fernano
Abstract: To perform MRI cerebellum volumetry in patients exposed to phenytoin and to identify factors associated with cerebellar atrophy (CA). From 100 consecutive epilepsy patients we selected those with phenytoin use for more than 2 months and with MRI scan available for volumetric studies. We obtained cerebellar volumes corrected for total intracranial volume. Volumes below 2 standard deviations from the mean of control group were considered abnormal. We studied 56 patients (33 women). Mean age was 33.6 years and mean duration of epilepsy was 17.6 years. Mean daily dose of phenytoin was 301 mg. CA was detected in 20 (35.7%) patients. CA was not associated with frequent generalised seizures. CA correlated with duration of epilepsy (r=-0.34; P=0.01) and years of treatment with phenytoin (r=-0.48; P=0.001), but not with age and mean daily dosage of phenytoin (P>0.05). However, a multiple correlation analysis as well as a backward stepwise multiple regression analysis including all variables showed that only duration of treatment was significantly associated with CA (P=0.001). CA is frequently associated with long-term use of phenytoin. Although duration of epilepsy may have an influence in the CA, this is clearly less important than the time of exposure to phenytoin.
Subject: Adolescent
Child, Preschool
Dose-response Relationship, Drug
Epilepsies, Partial
Epilepsy, Generalized
Epilepsy, Temporal Lobe
Epilepsy, Tonic-clonic
Image Processing, Computer-assisted
Long-term Care
Magnetic Resonance Imaging
Mathematical Computing
Middle Aged
Reference Values
Regression Analysis
Risk Factors
Citation: Seizure. v. 12, n. 5, p. 312-5, 2003-Jul.
Rights: fechado
Identifier DOI: 
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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