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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleLymphocyte Subpopulations During Cytomegalovirus Disease In Renal Transplant Recipients.pt_BR
dc.contributor.authorCastro, S Mpt_BR
dc.contributor.authorSporleder, Hpt_BR
dc.contributor.authorSchröeder, Rpt_BR
dc.contributor.authorSantos, Apt_BR
dc.contributor.authorGarcia, Vpt_BR
dc.contributor.authorNeumann, Jpt_BR
dc.contributor.authorCosta, S C Bpt_BR
unicamp.authorS M Castro, Departamento de Farmacologia, Faculdade de Ci ncias M dicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.pt_BR
unicamp.author.externalH Sporleder,pt
unicamp.author.externalR Schröeder,pt
unicamp.author.externalA Santos,pt
unicamp.author.externalV Garcia,pt
unicamp.author.externalJ Neumann,pt
unicamp.author.externalS C B Costa,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectAgedpt_BR
dc.subjectAnalysis Of Variancept_BR
dc.subjectB-lymphocytespt_BR
dc.subjectCytomegalovirus Infectionspt_BR
dc.subjectFemalept_BR
dc.subjectFlow Cytometrypt_BR
dc.subjectHumanspt_BR
dc.subjectImmunity, Cellularpt_BR
dc.subjectImmunosuppressive Agentspt_BR
dc.subjectKidney Transplantationpt_BR
dc.subjectKiller Cells, Naturalpt_BR
dc.subjectLymphocyte Activationpt_BR
dc.subjectLymphocytespt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectT-lymphocytespt_BR
dc.description.abstractWe have determined the number of circulating T, B and natural killer cells in renal transplant recipients in order to detect changes during cytomegalovirus (CMV) infections. Serial blood samples were taken from 61 patients on standard triple immunosuppression therapy (cyclosporin A, azathioprine and prednisone). Using two-color flow cytometry analysis, the absolute number of CD3+, CD4+, CD8+, CD19+, CD3+HLA-DR+ and CD16+56+ cells was determined. Forty-eight patients (78.7%) developed active CMV infection, and all of them subsequently recovered. Twenty of the infected patients (32.8%) presented symptoms compatible with CMV disease during the infectious process. The number of lymphocytes and their main subpopulations were normal before the onset of CMV disease. During the disease there was a decrease followed by a significant increase (P<0.005) in the number of CD3+, CD4+, CD8+ and CD3+HLA-DR+ cells. No significant changes were observed in natural killer cells or B lymphocytes during the disease. We conclude, as observed in all viremic patients recovering from infection, that recovery is associated with an increase in the number of T cell subsets. The monitoring of different lymphocyte subsets along with antigenemia can be extremely useful in the detection of patients at high risk of developing CMV symptoms, allowing the early introduction of antiviral therapy or the reduction of immunosuppression therapy.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.date.issued2003-Junpt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 36, n. 6, p. 795-805, 2003-Jun.pt_BR
dc.language.isoengpt_BR
dc.description.volume36pt_BR
dc.description.firstpage795-805pt_BR
dc.rightsabertopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.doipt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/12792710pt_BR
dc.date.available2015-11-27T12:52:11Z-
dc.date.accessioned2015-11-27T12:52:11Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:52:11Z (GMT). No. of bitstreams: 1 pmed_12792710.pdf: 813555 bytes, checksum: a4fb9e2098ef6b91cf218e89e6f5e717 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195410-
dc.identifier.idPubmed12792710pt_BR
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