Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195381
Type: Artigo de periódico
Title: Bioreabsorbable Polymer Scaffold As Temporary Meniscal Prosthesis.
Author: Testa Pezzin, Ana Paula
Cardoso, Túlio Pereira
do Carmo Alberto Rincón, Maria
de Carvalho Zavaglia, Cecília Amélia
de Rezende Duek, Eliana Aparecida
Abstract: Menisci have an important role in load bearing, shock absorption, knee joint stability, and joint lubrication. Meniscal lesions and meniscectomy are followed by osteoarthritis in a high percentage of patients. At present, there is no ideal prosthesis for meniscal substitution. In this work, a bioreabsorbable polymer scaffold made of poly(L-lactic acid) (PLLA) and poly(p-dioxanone) (PPD) blend was developed to be used as a temporary meniscal prosthesis to stimulate the formation of an in situ meniscal replication while the scaffold is reabsorbed by the organism. Total meniscectomy of medial meniscus and arthrotomy was made in both back knees of 34 adult New Zealand white rabbits by medial parapatellar incision. The scaffolds were sutured in one of the knees, and other was used as a control. A meniscal replica was developed, suggesting that this material has great potential to be used as a meniscal prosthesis, especially because the new meniscus promoted a significant protection of cartilage, and cartilage degeneration in the control condyles was observed.
Subject: Absorbable Implants
Animals
Biomechanical Phenomena
Cartilage, Articular
Dioxanes
Hindlimb
Knee Prosthesis
Menisci, Tibial
Microscopy, Electron, Scanning
Poloxalene
Polyesters
Porosity
Rabbits
Regeneration
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/12752202
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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