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Type: Artigo de periódico
Title: Axonal Sprouting In Mdx Mice And Its Relevance To Cell And Gene Mediated Therapies For Duchenne Muscular Dystrophy.
Author: Santo Neto, Humberto
Martins, Airton José
Minatel, Elaine
Marques, Maria Julia
Abstract: We investigated whether pre-terminal axons and motor terminals retained their ability to sprout in the murine X-linked muscular dystrophy (mdx). Immunofluorescence confocal microscopy observation of nerve terminals and acetylcholine receptors in mdx muscles with crushed and non-crushed nerves showed that most of the junctions had intraterminal sprouting and that the number of junctions with extraterminal sprouting increased after the nerve crush lesion. Since new dystrophin-positive muscle fibers generated by cell-mediated therapies need to be innervated to proceed with their maturation and dystrophin production, these results suggest that the use of inducing factors to increase the sprouting capacity of nerve terminals could be an additional tool in the success of cell-mediated therapies.
Subject: Animals
Genetic Therapy
Mice, Inbred C57bl
Mice, Inbred Mdx
Microscopy, Confocal
Microscopy, Fluorescence
Muscular Dystrophy, Duchenne
Neck Muscles
Nerve Crush
Nerve Regeneration
Neuromuscular Junction
Reference Values
Citation: Neuroscience Letters. v. 343, n. 1, p. 67-9, 2003-May.
Rights: fechado
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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