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Type: Artigo de periódico
Title: Total Synthesis Of (-)-pironetin.
Author: Dias, Luiz C
De Oliveira, Luciana G
De Sousa, Márcio A
Abstract: [structure: see text] The asymmetric total synthesis of pironetin, a compound that shows plant growth regulatory activity, immunosuppressive as well as a remarkable antitumoral activity, is described. The approach involves the use of three very efficient Evans oxazolidinone-mediated syn-aldol condensations, a high-yielding coupling between lithium acetylide ethylenediamine complex and a tosylate followed by methylation, and selective reduction to establish the C12-C13 (E) double bond.
Subject: Molecular Structure
Rights: fechado
Identifier DOI: 10.1021/ol027211o
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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