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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleNovel Signal Transduction Pathway For Luteinizing Hormone And Its Interaction With Insulin: Activation Of Janus Kinase/signal Transducer And Activator Of Transcription And Phosphoinositol 3-kinase/akt Pathways.pt_BR
dc.contributor.authorCarvalho, Carla R Opt_BR
dc.contributor.authorCarvalheira, José B Cpt_BR
dc.contributor.authorLima, Maria H Mpt_BR
dc.contributor.authorZimmerman, Suzana Fpt_BR
dc.contributor.authorCaperuto, Luciana Cpt_BR
dc.contributor.authorAmanso, Angélicapt_BR
dc.contributor.authorGasparetti, Alessandra Lpt_BR
dc.contributor.authorMeneghetti, Vainerpt_BR
dc.contributor.authorZimmerman, Leonardo Fpt_BR
dc.contributor.authorVelloso, Licio Apt_BR
dc.contributor.authorSaad, Mario J Apt_BR
unicamp.authorCarla R O Carvalho, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 13081-970 Campinas, Brazil.pt_BR
unicamp.author.externalJosé B C Carvalheira,pt
unicamp.author.externalMaria H M Lima,pt
unicamp.author.externalSuzana F Zimmerman,pt
unicamp.author.externalLuciana C Caperuto,pt
unicamp.author.externalAngélica Amanso,pt
unicamp.author.externalAlessandra L Gasparetti,pt
unicamp.author.externalVainer Meneghetti,pt
unicamp.author.externalLeonardo F Zimmerman,pt
unicamp.author.externalLicio A Velloso,pt
unicamp.author.externalMario J A Saad,pt
dc.subjectAnimalspt_BR
dc.subjectDna-binding Proteinspt_BR
dc.subjectFemalept_BR
dc.subjectInsulinpt_BR
dc.subjectInsulin Receptor Substrate Proteinspt_BR
dc.subjectJanus Kinase 2pt_BR
dc.subjectLuteinizing Hormonept_BR
dc.subjectMilk Proteinspt_BR
dc.subjectMitogen-activated Protein Kinasespt_BR
dc.subjectOvarypt_BR
dc.subjectPhosphatidylinositol 3-kinasespt_BR
dc.subjectPhosphoproteinspt_BR
dc.subjectPhosphorylationpt_BR
dc.subjectProtein-serine-threonine Kinasespt_BR
dc.subjectProtein-tyrosine Kinasespt_BR
dc.subjectProto-oncogene Proteinspt_BR
dc.subjectProto-oncogene Proteins C-aktpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectReceptor Cross-talkpt_BR
dc.subjectStat1 Transcription Factorpt_BR
dc.subjectStat5 Transcription Factorpt_BR
dc.subjectSignal Transductionpt_BR
dc.subjectTrans-activatorspt_BR
dc.subjectTyrosinept_BR
dc.subjectSrc Homology Domainspt_BR
dc.description.abstractThe actions of LH are mediated through a single class of cell surface LH/human chorionic gonadotropin receptor, which is a member of the G protein-coupled receptor family. In the present study we showed that LH induced rapid tyrosine phosphorylation and activation of the Janus kinase 2 (JAK2) in rat ovary. Upon JAK2 activation, tyrosine phosphorylation of signal transducer and activator of transcription-1 (STAT-1), STAT-5b, insulin receptor substrate-1 (IRS-1), and Src homology and collagen homology (Shc) were detected. In addition, LH induced IRS-1/phosphoinositol 3-kinase and Shc /growth factor receptor-binding protein 2 (Grb2) associations and downstream AKT (protein kinase B, homologous to v-AKT) serine phosphorylation and ERK tyrosine phosphorylation, respectively. The simultaneous infusion of insulin and LH induced higher phosphorylation levels of JAK2, STAT5b, IRS-1, and AKT compared with each hormone alone in the whole ovary of normal rats. By immunohistochemistry we demonstrated that these late events take place in follicular cells and both external and internal theca. These results indicate a new signal transduction pathway for LH and show that there is positive cross-talk between the insulin and LH signaling pathways at the level of phosphoinositol 3-kinase/AKT pathway in this tissue.en
dc.relation.ispartofEndocrinologypt_BR
dc.relation.ispartofabbreviationEndocrinologypt_BR
dc.date.issued2003-Febpt_BR
dc.identifier.citationEndocrinology. v. 144, n. 2, p. 638-47, 2003-Feb.pt_BR
dc.language.isoengpt_BR
dc.description.volume144pt_BR
dc.description.firstpage638-47pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0013-7227pt_BR
dc.identifier.doi10.1210/en.2002-220706pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/12538627pt_BR
dc.date.available2015-11-27T12:52:04Z-
dc.date.accessioned2015-11-27T12:52:04Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:52:04Z (GMT). No. of bitstreams: 1 pmed_12538627.pdf: 681612 bytes, checksum: 63d95cbe22f96eb0c26ad16c9e193cee (MD5) Previous issue date: 2003en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195358-
dc.identifier.idPubmed12538627pt_BR
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