Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195339
Type: Artigo de periódico
Title: Characteristics Of Nasal T/nk-cell Lymphoma Among Brazilians.
Author: Altemani, A
Barbosa, A C
Kulka, M
Takahashi, T
Endo, L
Vassallo, J
Lorand-Metze, I
Abstract: Nasal T/NK-cell lymphomas are highly associated with Epstein-Barr virus (EBV). They are more frequent in Asia than in Western countries. In Central and South America there are few studies about nasal T/NK-cell lymphoma and they have shown a strong predominance of this phenotype in Native American descents, supporting the hypothesis of a racial predisposition for the disease. We studied the lymphomas involving midline facial region at a Brazilian institution. T/NK cell lymphomas (16/25) were more frequently found compared to B lymphomas (9 cases, all B large cell). T/NK cell lymphomas involved predominantly the nasal region. Histologically they showed angioinvasion and necrosis. All of them were positive for CD3 and CD56 and showed numerous tumor cells labeled by EBER-1. Although disease was localized in 61% at diagnosis, there was no tendency to cure. The racial distribution of patients with T/NK-cell phenotype was similar to that found in B-cell lymphomas. EBV was more frequently found in adenoids than in palatine tonsils. In inflammatory lesions of the nasal and palatal regions EBV was not found. In the present study the relative frequency of T/NK versus B cell sinonasal lymphomas was high and similar to that observed in other Latin American countries. However, there was not any racial association with T/NK-cell phenotype and the tumor showed an agressive behavior similar to that reported in Asia. The high frequency of EBV-positive lymphocytes in nasopharyngeal lymphoid tissue (adenoids) suggests that they could serve as a reservoir for the virus.
Subject: Adult
Aged
Aged, 80 And Over
Brazil
European Continental Ancestry Group
Female
Genetic Predisposition To Disease
Herpesvirus 4, Human
Humans
Immunohistochemistry
Lymphoma, T-cell
Male
Medical Records
Middle Aged
Nose Neoplasms
Phenotype
Retrospective Studies
Survival Analysis
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/12044062
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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