Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195322
Type: Artigo de periódico
Title: Alpha-tricalcium Phosphate Cement: In Vitro" Cytotoxicity."
Author: dos Santos, L A
Carrodéguas, R G
Rogero, S O
Higa, O Z
Boschi, A O
de Arruda, A C F
Abstract: Calcium phosphate-based bioceramics have revolutionized orthopedic and dental repair of damaged parts of the bone system. Among these materials, calcium phosphate-based cements, with hydraulic setting, stand out due to their biocompatibility and in situ hardening, which allow easy manipulation and adaptation to the shape and dimensions of bone defects. An investigation was made of the in vitro cytotoxic effect of calcium phosphate cement based on alpha-tricalcium phosphate, immersed for different lengths of time in simulated body fluid (SBF), based on the ISO-10993 Biological Evaluation of Medical Devices standard. The culture medium was Chinese hamster ovary (CHO) cells in contact with diluted cement extracts. The results revealed that the calcium phosphate cement used was cytotoxic and that the material's cytotoxicity decreased the longer the cement was immersed in SBF.
Subject: Animals
Biocompatible Materials
Body Fluids
Bone Cements
Cho Cells
Calcium Phosphates
Cells, Cultured
Cricetinae
Hydrogen-ion Concentration
Inhibitory Concentration 50
Materials Testing
Microscopy, Electron, Scanning
Time Factors
X-ray Diffraction
X-rays
Citation: Biomaterials. v. 23, n. 9, p. 2035-42, 2002-May.
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/11996045
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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